| Exit | Roads | City | Hotels |
| Interstate 5 in California | |||
| (mile 0 - California stateline) | |||
| 1 | Siskiyou Summit, Old Hwy 99 | ||
| 6 | Mt. Ashland, Old Hwy 99 | ||
| 11 | OR 99 (Siskiyou Boulevard) | Ashland | |
| 14 | OR 66, Ashland St | Ashland | ★★★★★ Holiday Inn Express Hotel & Suites Ashland ★★★★★ Best Western Windsor Inn |
| 19 | Valley View Road | Ashland | ★★★★★ Comfort Inn & Suites Ashland |
| 21 | Valley View Road | Talent | |
| 24 | Fern Valley Road, Phoenix Road | Phoenix | |
| 27 | Highland Drive, Garfield Street | Medford | ★★★★★ Homewood Suites by Hilton Medford ★★★★★ Hilton Garden Inn Medford ★★★★★ TownePlace Suites Medford ★★★★★ SpringHill Suites Medford ★★★★★ Clarion Inn and Suites Medford ★★★★★ Holiday Inn Express & Suites Medford ★★★★★ Best Western Horizon Inn ★★★★★ Fairfield Inn & Suites Medford ★★★★★ Comfort Inn Medford South ★★★★★ Days Inn by Wyndham Medford |
| 30 | OR 62 (Crater Lake Hwy), to OR 238 | Medford | ★★★★★ Hampton Inn Medford ★★★★★ SpringHill Suites Medford Airport ★★★★★ Ramada by Wyndham Medford Airport North ★★★★★ Comfort Inn Medford North ★★★★★ Quality Inn and Suites Medford Airport |
| 33 | Pine St | Central Point, Medford | ★★★★★ Holiday Inn Express Hotel & Suites Medford-Central Point ★★★★★ Super 8 by Wyndham Central Point Medford |
| 35 | OR 99 (Rogue River Hwy), Blackwell Road | Central Point | |
| 40 | OR 234 (Sams Valley Hwy) | Gold Hill | |
| 43 | To OR 99 (Rogue River Hwy), to OR 234 | ||
| 45A | OR 99 (Rogue River Hwy) | ||
| 45B | Valley of the Rogue State Park | ||
| 48 | Depot St, Rogue River | Grants Pass, Rogue River | ★★★★★ Best Western Inn at the Rogue |
| 55 | US 199 (Redwood Highway, Grants Pass Pkwy) | Grants Pass | ★★★★★ Holiday Inn Express Grants Pass ★★★★★ Best Western Grants Pass Inn |
| 58 | OR 99 (NW 6th St) | Grants Pass | ★★★★★ Hampton Inn & Suites Grants Pass ★★★★★ Quality Inn Grants Pass ★★★★★ Travelodge by Wyndham Grants Pass ★★★★★ Super 8 by Wyndham Grants Pass |
| 61 | Monument Rd, Merlin Rd | Merlin | |
| 66 | Monument Dr | Hugo | |
| 71 | Sunny Valley Loop | Sunny Valley | |
| 76 | Old Hwy 99 | Wolf Creek | |
| 78 | Speaker Road | ||
| 80 | Glendale Valley Road | Glendale | |
| 83 | Barton Road | ||
| 86 | Quines Creek Road | ||
| 88 | Azalea-Glen Road | Azalea | |
| 95 | Canyon Creek Forest State Park | ||
| 98 | Canyonville-Riddle Road, 1st Street | Canyonville | ★★★★★ Travelodge by Wyndham Canyonville |
| 99 | Stanton Park Road | Canyonville | |
| 101 | Yokum Road | Riddle | |
| 102 | Gazley Road | ||
| 103 | Pruner Road, Gael Lane | Tri-City | |
| 106 | Weaver Road | ||
| 108 | Main Street (OR 99) | Myrtle Creek | |
| 110 | Boomer Hill Road | ||
| 112 | OR 99 (Dillard Hwy) | ||
| 113 | Clarks Branch Road | ||
| 119 | OR 42 | Green | |
| 120 | OR 99 | ||
| 121 | McLain Avenue | ||
| 123 | Douglas County Fairground | ||
| 124 | OR 138 (Harvard Ave) | Roseburg | ★★★★★ Holiday Inn Express Roseburg |
| 125 | Garden Valley Boulevard | Roseburg | ★★★★★ Hampton Inn & Suites Roseburg ★★★★★ Holiday Inn Express & Suites Roseburg North ★★★★★ Best Western Garden Villa Inn ★★★★★ Comfort Inn Roseburg ★★★★★ Quality Inn Roseburg Central |
| 127 | Edenbower Boulevard | Roseburg | ★★★★★ Sleep Inn & Suites Roseburg ★★★★★ Super 8 by Wyndham Roseburg |
| 129 | OR 99 (Del Rio Road) | ||
| 135 | OR 99 | Sutherlin | |
| 136 | OR 138 (Elkton-Sutherlin Hwy, Central Ave) | Sutherlin | ★★★★★ Best Western Plus Hartford Lodge |
| 138 | Stearns Lane | Oakland | |
| 140 | OR 99 | Oakland | |
| 142 | Metz Hill Road | ||
| 146 | Rice Valley Road | ||
| 148 | Rice Hill | Oakland | |
| 150 | OR 99 | ||
| 154 | Scotts Valley Road | ||
| 159 | Cox Road | ||
| 160 | Salt Springs Road | ||
| 161 | Anlauf, Lorane | ||
| 162 | OR 99 (Umpqua Hwy) | ||
| 163 | Bear Creek Rd | Curtin | |
| 170 | OR 99 (Goshen-Divide Hwy) | ||
| 172 | 6th Street | Cottage Grove | |
| 174 | Cottage Grove, Row River Road | Cottage Grove | ★★★★★ Best Western Cottage Grove Inn |
| 176 | Saginaw Road | Cottage Grove | |
| 182 | Oregon Ave, Cloverdale Rd | Creswell | ★★★★★ Comfort Inn & Suites Creswell |
| 186 | Dillard Road | ||
| 188A | OR 58 (Willamette Highway), OR 99 | ||
| 189 | 30th Avenue (OR 225), Franklin Blvd | Eugene | |
| 191 | Glenwood Blvd | Eugene | |
| 192 | OR 99 (OR 126 Bus, Franklin Blvd) | Eugene | ★★★★★ Candlewood Suites Eugene Springfield ★★★★★ Fairfield Inn & Suites Eugene East Springfield ★★★★★ Comfort Suites Eugene |
| 194 | I-105, OR 126 | Springfield | |
| 195 | OR 569 (Beltline Rd) | Springfield | ★★★★★ Holiday Inn Eugene - Springfield ★★★★★ Courtyard Eugene Springfield ★★★★★ Hilton Garden Inn Eugene/Springfield ★★★★★ Best Western Grand Manor Inn ★★★★★ Comfort Suites Springfield ★★★★★ Spark by Hilton Springfield Eugene ★★★★★ Quality Inn & Suites Springfield |
| 199 | Pearl St, Van Duyn Rd | Coburg | |
| 209 | Diamond Hill Drive | Harrisburg | |
| 216 | OR 228 (Halsey-Sweet Home Hwy)) | Halsey | ★★★★★ Travelodge by Wyndham Pioneer Villa |
| 228 | OR 34 (Corvallis-Lebanon Hwy) | ||
| 233 | US 20 (Santiam Highway) | Albany | ★★★★★ Best Western Plus Prairie Inn ★★★★★ Rodeway Inn Albany |
| 234A | Linn County Fair and Expo Center | Albany | |
| 234B | OR 99E (Pacific Blvd), Knox Butte Rd | Albany | ★★★★★ Holiday Inn Express Hotel & Suites Albany ★★★★★ Comfort Suites Linn County Fairground and Expo Albany ★★★★★ Quality Inn & Suites Albany ★★★★★ Super 8 by Wyndham Albany |
| 235 | Viewcrest, Millersburg | Millersburg | |
| 237 | Viewcrest Drive | Millersburg | |
| 238 | OR 99, OR 164 | Millersburg | |
| 239 | Dever-Conner Road | ||
| 242 | Talbot Road | ||
| 243 | Ankeny Hill Road | ||
| 244 | OR 264 (Jefferson Hwy) | ||
| 248 | Delaney Road | ||
| 249 | Commercial Street | Salem | |
| 252 | Kuebler Boulevard | Salem | |
| 253 | OR 22/OR 99E Bus (Mission St, Santiam Hwy) | Salem | ★★★★★ Residence Inn Salem ★★★★★ Hampton Inn & Suites Salem ★★★★★ Best Western Plus Mill Creek Inn ★★★★★ Comfort Suites Salem Airport |
| 256 | OR 213 (Market Street) | Salem | ★★★★★ DoubleTree by Hilton Hotel Salem ★★★★★ Home2 Suites by Hilton Salem ★★★★★ Comfort Inn & Suites Salem ★★★★★ Days Inn by Wyndham Black Bear |
| 258 | OR 99E (Pacific Highway East, Portland Rd) | Salem | ★★★★★ Rodeway Inn Salem |
| 260A | OR 99E Bus (Salem Parkway) | Salem | |
| 260B | Chemawa Road, Hazel Green Rd | Keizer | ★★★★★ Holiday Inn Express & Suites Keizer |
| 263 | Brooklake Rd | Brooks | |
| 271 | OR 214 (Newberg Hwy) | Woodburn | ★★★★★ Best Western Woodburn ★★★★★ Super 8 by Wyndham Woodburn |
| 278 | Ehlen Rd, Aurora | ||
| 282A | Wilsonville-Hubbard Hwy | ||
| 282B | Miley Rd, Charbonneau District | ||
| 283 | Wilsonville Rd | Wilsonville | ★★★★★ Hilton Garden Inn Wilsonville ★★★★★ Best Western Wilsonville Inn & Suites ★★★★★ Quality Inn Wilsonville |
| 286 | Elligsen Rd, Boones Ferry Rd | Wilsonville | ★★★★★ Holiday Inn Portland I-5 S (Wilsonville) ★★★★★ Best Western Plus Parkway Inn |
| 288 | I-205 | Tualatin | |
| 289 | Nyberg St, Tualatin-Sherwood Rd | Tualatin | ★★★★★ Comfort Inn & Suites Tualatin |
| 290 | Lower Boones Ferry Road, Bridgeport Rd | Lake Oswego, Tigard | |
| 291 | Carman Drive, Upper Boones Ferry Rd | Lake Oswego, Tigard | ★★★★★ Courtyard Portland Tigard ★★★★★ Holiday Inn Express Portland South - Lake Oswego |
| 292 | OR 217, Kruse Way, 72nd Avenue | Lake Oswego, Tigard | ★★★★★ AC Hotel Lake Oswego ★★★★★ AC Hotel Lake Oswego ★★★★★ Residence Inn Portland South/Lake Oswego ★★★★★ Hilton Garden Inn Portland/Lake Oswego ★★★★★ Best Western Lake Oswego Hotel & Suites ★★★★★ Fairfield Inn & Suites Portland South/Lake Oswego |
| 293 | Haines Street | Tigard | ★★★★★ Hampton Inn & Suites Portland Tigard |
| 294 | OR 99W (Barbur Blvd) | Tigard | ★★★★★ Comfort Suites Portland Southwest |
| 295 | Capitol Highway, Taylors Ferry Road, Barbur Blvd | Portland | |
| 296A | Barbur Blvd | Portland | |
| 296B | Multnomah Boulevard | Portland | |
| 297 | Terwilliger Boulevard | Portland | |
| 298 | Corbett Avenue | Portland | |
| 299A | OR 43 (Macadam Avenue, Hood Avenue) | Portland | ★★★★★ Residence Inn Portland Downtown/RiverPlace |
| 299B | I-405 | Portland | |
| 300B | OR 99E, Morrison St, Belmont St | Portland | |
| 301 | Interstate 84 (US 30) | Portland | |
| 302A | Weidler Street, Broadway | Portland | ★★★★★ Crowne Plaza Portland-Downtown Convention Center ★★★★★ Courtyard Portland Downtown/Lloyd Center ★★★★★ Hotel Eastlund Best Western Premier Collection ★★★★★ Quality Inn Portland Downtown Convention Center |
| 302B | I-405, US 30 | Portland | |
| 302C | Greeley Avenue | Portland | |
| 303 | Killingsworth Street, Alberta Street | Portland | |
| 304 | Rosa Parks Way | Portland | |
| 305 | Lombard Street (US 30) | Portland | |
| 306A | Columbia Boulevard | Portland | |
| 306B | Interstate Avenue - Expo Center | Portland | ★★★★★ Country Inn & Suites by Radisson, Portland Delta Park |
| 307 | OR 99E (Martin Luther King Jr. Boulevard), Marine Drive | Portland | ★★★★★ Courtyard Portland North Harbour ★★★★★ Residence Inn Portland North Harbour ★★★★★ Fairfield Inn & Suites Portland North Harbour |
| 308 | Jantzen Beach | Portland | ★★★★★ Holiday Inn Portland - Columbia Riverfront ★★★★★ Holiday Inn Express Hotel & Suites Portland-Jantzen Beach |
| (mile 308 - Washington state line) |