One of four Staybridge Suites hotels in San Antonio, this has a northwesterly location along I-10, 7 miles from the city center - on the east side of the highway between exits 561 and 562. This area of San Antonio is mostly residential but there are many other businesses and hotels along the I-10 corridor, and the main medical district is one mile southwest. In the middle of the hotel complex is an outdoor pool and recreation courts, and other amenities include a convenience store, fitness center and complimentary breakfast buffet.

The Candlewood Suites in San Antonio is another of the many hotels along the I-10 corridor, northwest of the city center; on the west side of the interstate near exit 561 (Wurzbach Rd). The 112 large, modern suites all have a full kitchen including dishwasher & refrigerator with ice maker, executive desk with 2 phone lines, CD & DVD players, and free high speed internet connection. Guests can purchase snacks and food for cooking at the on-site convenience store, or eat out at one of the numerous restaurants nearby. Other amenities at the Candlewood Suites are a free movie/book library, an outdoor pool, barbeque grills and a fitness center.

The Holiday Inn Express San Antonio Northwest hotel opened in 2005 in a mostly tree-lined, residential neighborhood alongside I-10, 12 miles from the city center. The location is 4800 Woodstone Road, 1/4 mile northwest of exit 559 of the interstate and within 2 miles of University of Texas at San Antonio, and the city's medical district. The main facilities are an outdoor pool, fitness center and free continental breakfast.

The newly built (2008) Holiday Inn Express hotel in northwest San Antonio is a well regarded, reasonably priced establishment offering 80 comfortable rooms, free hot breakfast, free internet access, an outdoor pool/hot tub, and a fitness center. All rooms have a microwave & refrigerator, and look out over a mostly residential area at the Vance Jackson exit of I-10, 1.5 miles from the intersection with I-410. Nearby places include the Crossroads Mall, Central Park Mall, South Texas Medical Center and Oak Hills Country Club; downtown San Antonio is 6 miles south. There are plenty of restaurants nearby, on the far (north) side of the interstate.

Not to be confused with the Best Western Posada Inn near the airport, this hotel is in the northwest suburbs of San Antonio along I-10 at 9411 Wurzbach Rd, just southwest of exit 561 of the interstate. As well as the main medical/hospital district of San Antonio, a mile further southwest along Wurzbach Rd, the hotel is also well located for the many businesses in this part of town, and is still within easy reach of downtown and attractions like SeaWorld, 10 miles west. The inn is a 79 room, 4 floor building with an outdoor pool, fitness center and breakfast bar.

San Antonio Marriott Northwest offers clean, modern facilities to business or leisure travelers to this part of the city, and has a prominent location right beside the I-10/I-410 intersection; it is 5.5 miles from the international airport, close enough to provide a free shuttle service. On entry, guests are greeted by an elegant, 4 storey atrium lobby, location of the business center and lounge, while other interior facilities are a restaurant, gift shop, fitness center and 8,445 sq ft of meetings space. The grounds contain an outdoor pool and a small garden area.

Adjacent to the main hospital/medical center in San Antonio, the Courtyard by Marriott hotel is a quiet place to stay, set a little way back from the main street (Fredericksburg Rd), in a semi-residential area. Other sites in town are easily reached via interstate 10 which runs by one mile east. The hotel is an older building though quite recently renovated, and has amenities of an outdoor pool, fitness center, business center, 24 hour market, and a cafe serving breakfast.

Although alongside I-10, the Residence Inn San Antonio Northwest enjoys a quiet location in a residential district next to the USAA company headquarters, about 10 miles from the city center. The hotel has the older layout for this brand, with its 128 large suites (all containing a full kitchen) divided into several separate, 2-floor blocks, part of quite a large site that also includes a sports court, outdoor pool and hot tub. Free hot breakfast is provided and there are several restaurants within walking distance, around exit 562 of the interstate (Wurzbach Rd).

Open 2007, the new TownePlace Suites hotel in northwest San Antonio provides good quality, reasonably priced, long stay accommodation in 123 studio suites that contain a full kitchen, large work desk, and separate living/sleeping areas. Both free full breakfast & free evening light dinner (Mon-Thu) are provided, and there is a reasonable selection of restaurants one block away around the Huebner Rd exit of interstate 10. The hotel operates a complimentary shuttle to places within a 3 mile radius, including the San Antonio Medical Center complex.

The SpringHill Suites hotel in San Antonio has good road connections, located right next to the junction of I-10 and I-410 on northwest side of town, adjacent to the Crossroads Mall and near to many restaurants. The Medical Center is 3 miles north, and downtown San Antonio 8 miles south along I-10. Contained within the 5 floor building are 112 large suites - containing a kitchen area with sink, microwave & refrigerator - plus a fitness center, guest laundry, full service business center, dining area where free full breakfast is provided, and 3 meeting rooms.

The third SpringHill Suites hotel to open in San Antonio is built alongside I-10 near exit 558 (De Zavala Rd), ten miles northwest of the city center - in a relatively quiet, wooded neighborhood close to South Texas Medical Center. Accommodation comprises 109 comfortable studio suites featuring a pantry (sink, microwave, refrigerator), work desk, free internet access and the luxurious Marriott bedding. Free breakfast buffet is prepared each morning, and there are several dozen restaurants within a mile, some just a short walk away.

Sites within 3 miles of Comfort Inn Medical Center include Ingram Park Mall, Crossroads Mall, Oak Hills Country Club and of course the South Texas Medical Center. The inn faces I-410 (south side), near many restaurants, shops and other businesses, and 4 miles from I-10. Guests can relax in a sheltered outdoor pool & hot tub at the rear of the property; inside, the main amenities are free continental breakfast, free internet access, laundry and a small meeting room. The 55 guest rooms are clean, if a little dated, and all contain a microwave/refrigerator.

New for 2009, the Comfort Inn San Antonio at 6039 I-10 West (the Vance Jackson exit) caters for guests in 82 spacious, well presented rooms & suites, all equipped with a microwave, refrigerator and flat screen TV; some have one or more of a whirlpool bath, wet bar and pull-out sofa. Free continental breakfast is served and there are two restaurants adjacent plus plenty more close by, and also a Wal-Mart just across the road. The pet friendly hotel has a good range of amenities, principally a pool, hot tub, exercise room, business center, copy/fax service and free internet access.

San Antonio's Sleep Inn has a northwesterly location along the I-10 frontage road (west side), half a mile south of exit 560 (Medical Dr), and is less than a mile from the various hospitals of the South Texas Medical Center. Despite the proximity of the interstate this is a quiet location, with a wooded, residential district to the west. The hotel has an outdoor pool at the rear and serves free continental breakfast.

Econo Lodge Central provides budget accommodation in 57 clean and functional guest rooms, part of a two storey, exterior corridor building on the north side of interstate 10 at the Vance Jackson exit, 5 miles from downtown San Antonio. There are many restaurants and shops nearby, including Wal-Mart just across the street and Crossroads Mall 1.5 miles away by the I-410 junction. The motel offers free continental breakfast, free internet access and copy/fax services.