Holiday Inn Express Bernalillo is located a mile north of the town center close to major highways - the hotel lies one block west of I-25 exit 242, at the intersection of US 550 with NM 313 (Camino del Pueblo), though is set back slightly from the main road, along Bell Lane. This is a rural/residential area, a mile from the Rio Grande River and close to the edge of the Santa Ana Indian Reservation to the west. Downtown Albuquerque is 16 miles south, and Santa Fe is 50 miles north; important sites nearby are the Santa Ana Golf Club and Coronado State Park. The hotel is clean, modern and well managed, with 70 rooms on 3 floors, an indoor pool, hot tub, health & fitness center and dining area for the free Express Start continental breakfast.

With a conspicuous location right next to I-25 (exit 242: US 550), Quality Inn & Suites Bernalillo is a good choice for long distance travelers on the interstate, or those visiting nearby Albuquerque, the Indian Pueblos, the Jemez Mountains or the Tent Rocks National Monument (35 miles north). The inn is a new-looking building of 3 floors and 57 smallish rooms, offering good customer service, reasonable rates and a high standard of cleanliness. Free full breakfast and free local area shuttle are the two main amenities.