The all suite Staybridge Suites San Francisco Airport caters primarily to the extended stay traveler but is well suited to short visits as well. It is a 3.3 mile drive from the airport, on the north side of San Bruno near the adjacent town of South San Francisco, and well connected to all other places by US 101 a few blocks east, I-280 just west, and the San Bruno BART station 0.4 miles south. The neighborhood has many restaurants and large stores, including those of the Shops at Tanforan mall, within walking distance. Like all Staybridge Suites, the hotel is a new building providing high quality accommodation and facilities, which here include free continental breakfast, free 5 mile local area shuttle, an outdoor pool, convenience store, fitness center, whirlpool, sports court, and 6 meeting rooms.

San Bruno's Courtyard by Marriott hotel has the typical design for this brand with the 147 rooms & suites (on 2 floors) built around a landscaped courtyard garden featuring mature trees, flowers, footpaths and a gazebo, though not in this case a swimming pool as that is inside, next to the hot tub. Rooms are large & clean, and the hotel serves freshly cooked breakfast in a cafe off the lobby, but perhaps the best aspect is the central location - a short walk from many restaurants and shops including at the Tanforan Mall, one mile from the San Bruno BART station, right next to I-380 half way between I-280 & US 101, and 3 miles from San Francisco International Airport (served by free shuttle).

Along busy El Camino Real through the center of San Bruno, the new Villa Montes, an Ascend Collection Hotel (formerly part of the Clarion Collection) is a small but elegant boutique-style property providing a superior standard of accommodation in its 41 well furnished rooms, some of which feature a wet bar, balcony and extra sofa bed (all have refrigerator/microwave). Both free breakfast (full) and a free evening wine reception are served, with other meals available from a group of restaurants one block north on El Camino Plaza. The above average range of amenities includes a fitness center, large hot tub, sauna, sun deck, convenience store, meeting/banquet facilities, a free shuttle to San Francisco Airport (just 2.5 miles away), and a spa with on-site massage therapist.

A little way north of the center of San Bruno, CA, the Comfort Inn & Suites is a compact, 3 floor hotel, 2 miles by road from the international airport (served by free shuttle), and 12 miles from downtown San Francisco. The building has one unusual feature in a central courtyard with ornate fountain, and it has generally bright, spacious and modern rooms, all with microwave/refrigerator, and some containing a wet bar and whirlpool bath. Free deluxe continental breakfast is available; for other meals there is one restaurant (pizza) close by though a better selection half a mile away along San Mateo Avenue. Road connections are good, with the US 101 - I-380 interchange just 3 blocks away.