The full service Holiday Inn Palm Springs was closed for some time whilst undergoing a full renovation, but reopened to guests in January 2008. This is one of the bigger Palm Springs hotels, offering 249 rooms & suites on 3 floors, arranged around a large garden/courtyard with outdoor pool & hot tub, and located at the northeast corner of the junction of E Palm Canyon Dr with S Sunrise Way. This part of Palm Springs is mostly residential, 2 miles from downtown, and close to the edge of the hills - many rooms have views over the Santa Rosa and San Jacinto ranges just to the south. The hotel has an on-site restaurant, bar/lounge, fitness center and 8,000 sq ft of meetings space.

Palm Spring's Courtyard hotel has a typical design for this brand, with the 149 rooms & suites in 2 blocks enclosing a pretty courtyard garden that contains an outdoor pool, hot tub, palm trees and other tropical plants. Rooms are clean and the staff are friendly and efficient. The main amenities are a cafe (open for breakfast only), a 24 hour convenience store, a fitness center and a complimentary shuttle to Palm Springs Airport (1.4 miles east). Surrounding the hotel is a mixture of private residences and as yet undeveloped desert - the main center of Palm Springs is a mile west, along Tahquitz Canyon Way.

The 72 room Best Western Inn at Palm Springs is located at the junction of S and E Palm Canyon Drive, 0.75 miles from downtown and right at the western edge of the suburbs - the pool and many of the rooms overlook the desert foothills of the San Jacinto Mountains, and the hotel is just far enough from the main road to enjoy peace and quiet, yet still be within a short walk of various restaurants and bars. Free continental breakfast is served by the pool, which is open 24 hours a day. The most popular hiking destination in Palm Springs - the Indian Canyons - is a 5 minute drive away along S Palm Canyon Dr.

Right at the center of Palm Springs, Best Western Las Brisas offers 90 comfortable rooms in a Mediterranean-style building complete with outdoor pool, tropical gardens, sundeck and poolside bar. The hotel is located at the corner of S Indian Canyon Dr (CA 111 northbound) and E Arenas Rd, within 2 blocks of many restaurants and shops, and 2.5 miles from the international airport. The many amenities include free full American breakfast, 2 cocktail lounges, restaurant (La Terraza Grill), concierge service, coffee shop and guest laundry.

Like many hotels in Palm Springs, the Comfort Inn has a central location along CA 111, on the northbound side (N Indian Canyon Dr), one block north of Ramon Road which provides the closest access from I-10 for westbound travelers, as well as passing Palm Springs International Airport after 5 miles. The inn is quite a large building just off the main highway, with 130 rooms on 3 floors, and 2 outdoor pools surrounded by palm trees, both benefiting from the outdoor cooling mist system quite common in Palm Springs. A wide selection of shops, restaurants and entertainment is within easy walk of the hotel.

At 1269 E Palm Canyon Drive, The Quality Inn hotel is 2 miles southeast of downtown Palm Springs along CA 111, the main road through the resort cities, and occupies a sizeable area on the south side of the highway, in a residential area. The accommodation blocks (124 rooms, 2 floors) are surrounded by palm-lined carparks, gardens, two restaurants and the outdoor pool/hot tub, and are close to several cocktail lounges and other restaurants, though most facilities are in the downtown area. The international airport is 2 miles northeast.