I-10 passes within a few miles of the north edge of Kofa National Wildlife Refuge, and the northeast corner is accessed by Vicksburg Road from exit 45, but most approaches are from the west, via side tracks off US 95 between Yuma and Quartzsite. Major routes are, from south to north, Castle Dome Mine Road, King Road, Palm Canyon Road, MST&T Road and Blevens Road.