The Holiday Inn is a substantial, modern, four floor building just off Grand Avenue towards the east side of Laramie, a few blocks from University of Wyoming and 2 miles from I-80 (exit 316). The neighborhood is quiet, partly residential, but with several small restaurants and small shops within walking distance. Full service amenities at the Holiday Inn comprise a family restaurant (Perkins - room service available), a lounge/bar that also serves food, a pool/hot tub/fitness center, gift shop, laundry, 24 hour business center and meetings space for up to 250 guests. The 100 rooms & suites have luxurious bedding, a microwave, refrigerator and HDTV.

Marriott are represented in Wyoming's third city by Fairfield Inn Laramie, built 2008 in a countryside setting beside I-80 right at the north edge of town; not near any shops or restaurants apart from the adjacent Turtle Rock Coffee, open for breakfast lunch & dinner. The hotel's 82 rooms are nicely decorated in bright colors, and all feature a work desk, coffee maker and free internet access; the suites have added amenities of a refrigerator, microwave, entertainment center and separate living area. Leisure facilities are the usual pool (indoor), hot tub and fitness center. Free breakfast buffet is served each morning, including several hot items.

Most rooms at the Best Western hotel in Laramie have views across empty plains towards distant mountains - the hotel has a countryside setting just beyond the north edge of the city, close to I-80 exit 310 (Curtis St). There are several gas stations and fast food places nearby but a much better selection of restaurants can be found one mile east along US 30 in the center of Laramie. The hotel is a fairly standard establishment, relatively new, with a microwave/refrigerator in each of the 62 rooms, and amenities of free continental breakfast, an indoor pool/hot tub, fitness room, business center and laundry.

Comfort Inn Laramie is situated towards the east side of the city along Grand Avenue, a busy street of shops, restaurants and other businesses, though with undeveloped land just a short distance away to the north and south. The hotel has a good reputation, for the excellent staff, the clean and well equipped rooms (all have a refrigerator & microwave) and the above average free continental breakfast. The place is quite small, just 55 rooms, including several suites with a kitchen and separate living area. A fitness center, indoor pool, hot tub, laundry, newsstand and free internet access are the other amenities.

Laramie's Quality Inn faces open countryside on the west side of interstate 80 next to exit 310, Curtis St, which leads to the city center 3 miles southeast. There isn't much in the neighborhood apart from one restaurant and a truck stop; the nearest shops are about a mile away. There are 72 rooms at the hotel - large and well maintained, and equipped with a work desk, refrigerator, coffee maker and microwave. Some have additional amenities of a balcony, wet bar and hot tub bath. Other facilities are the usual free continental breakfast, a pool, whirlpool, fitness room and sun deck.

Facilities are quite basic, but rates at Econo Lodge Laramie are low, and the place is generally clean and welcoming. The red roofed, interior corridor inn offers free internet access, a pool, games room, laundry and free continental breakfast; other meals can be purchased from a couple of nearby fast food restaurants. The inn is situated 3 miles northwest of the city center close to to exit 310 of I-80, a few minutes walk from the Laramie River.

The Motel 6 is one of the few hotels on the south side of Laramie - part of a small group of buildings next to the US 287/I-80 intersection, 1.5 miles from the city center. The small but clean and functional rooms are divided into three adjacent blocks arranged around an outdoor pool and garden; inside, facilities comprise wi-fi, free coffee, cable TV, laundry, and a mini refrigerator in some of the rooms. Meals are provided by a couple of restaurants within walking distance.