The full service Holiday Inn hotel in Casper opened summer 2008 close to I-25 exit 182, about 6 miles east of the city center, and 2 miles from Eastridge Mall. The hotel's 120 rooms & suites are large, comfortable and modern, and the property provides all necessary services for business (meeting/conference facilities, free internet access, business center) and leisure (indoor pool, hot tub, fitness center, patio). The on-site Cole Creek bar/grill serves breakfast, lunch and dinner, plus room service until 10 pm. Many of the rooms have nice views south towards the Laramie Mountains. The hotel operates a complimentary 10 mile local area shuttle, including to Natrona County Airport (NAT) .

Marriott are represented in Casper by the newly built Courtyard hotel at 4260 Hospitality Lane, towards the east edge of town beside I-25 exit 185 - part of a busy area of shops and restaurants extending half a mile south to Eastridge Mall. Also nearby are the Casper Events Center and the Hilltop Shopping Center. The Courtyard is a substantial, modern property of 100 refrigerator/microwave-equipped rooms & suites, and it has a good range of amenities: an indoor pool/spa, fitness center, full srvice business center, 24 hour convenience store, free internet access, and the Courtyard Cafe which serves buffet or cooked-to-order breakfast. There are many restaurants close by to provide other meals.

Rooms at the Holiday Inn Express hotel in Casper are clean, modern and nicely decorated, part of a recently constructed 4 floor building at the edge of the main shopping area in town, beside I-25 exit 185. Free hot breakfast is prepared each morning, and there are many restaurants within walking distance plus a good selection of stores including Wal-Mart and the 90-outlet Eastridge Mall. Leisure facilities are the usual pool, hot tub and fitness center, while for those here to work the hotel has a business center and meeting space for up to 40 people. Besides the regular accommodation, there are 12 suites available, featuring a mini bar and a whirlpool bath.

On the west side of Casper next to I-25 exit 188B, the 229 room Best Western Ramkota Inn has full service amenities including its own restaurant/bar (Remington, open for breakfast, lunch & dinner), and a large indoor pool complete with family water park (Castaway Bay). The hotel rises 6 storeys above the city, high enough for most rooms to have good views of the surrounding mountains and the North Platte River, which flows past just to the east. Also available are a fitness center, beauty shop, games room, and conference space for up to 1000 guests. Although the building is fairly old, the rooms are well maintained, and some have extra facilities such as a balcony, sofa bed, mini bar and hot tub bath.

The Quality Inn is a west Casper hotel, easily accessed from I-25 which runs past one end of the building. A selection of restaurants are close by, and the Casper Events Center is just up the street, though undeveloped countryside is just a short drive away further west. Also nearby is a pleasant footpath along the banks of the North Platte River. The hotel is quite large (92 rooms), clean, and has slightly above average facilities; the free continental breakfast includes several hot items, while other amenities comprise a well-equipped fitness center, free internet access, a business center, meeting space, laundry and newsstand. Several two-room suites are available, featuring a hot tub bath, microwave and refrigerator.

The MainStay Suites is a good choice for affordable extended stay accommodation in Casper, offering a full kitchen (stove, dishwasher, microwave, refrigerator) in each of its 93 spacious rooms, some of which have a balcony. Continental breakfast, internet access, local calls, guest laundry, DVD rentals and managers reception are all provided free of charge, while leisure facilities are the expected pool, hot tub and fitness center. The hotel is quite new, built 2008 in a mostly rural neighborhood right on the east side of town near I-25 exit 182 (Hat 6 Rd) - a couple of miles from the nearest main center for shopping/dining, at Eastridge Mall.

Casper's Motel 6 is a typically basic but clean and low price establishment, located at the edge of the countryside on the west side of town, and occupying a slightly elevated site that allows nice long distance views of the city to the east and the mountains to the south. Interstate 25 runs past to one side and there are a few fast food restaurants within walking distance. Facilities are an outdoor pool, laundry, free coffee, cable TV, wi-fi, and a refrigerator in some of the rooms. Pets are welcome.