The newest hotel in Buffalo opened summer 2008 in the countryside along US 16 on the east edge of town; the 69 room/suite Holiday Inn Express enjoys long distance views towards the Bighorn Mountains, and has a quiet location, yet is within two miles of the shops, restaurants, galleries and historic buildings in the downtown area. Guests are treated to free hot breakfast each morning, and can take advantage of a good range of amenities including an indoor pool, hot tub, fitness center, newsstand (offering a free daily paper), business center, laundry and free internet access.

Towards the east side of Buffalo, the 60 room Best Western Crossroads Inn is an older, exterior corridor property that has been partly updated, and offers generally clean and friendly accommodation with amenities of a sheltered outdoor pool at the rear, a hot tub, free internet access and a business center. A restaurant/bar right next door provides all-day dining and live entertainment in the evenings. The inn is easily accessed from I-25 exit 299 (E Hart St; US 16), and is within a short walk of shopping and dining in Buffalo town center.

Comfort Inn Buffalo is known for its clean rooms, reasonable rates and pleasant location, adjacent to I-25 exit 299 (east side) - the hotel has a generally rural setting, backing on to a small wooded stream (Clear Creek); a trail runs alongside. There are several restaurants a short distance west, on US 16 which leads to the historic center of Buffalo after 1 mile. The two storey, pet friendly, interior corridor inn features basic free continental breakfast, free internet access, an exercise room, an indoor pool and a hot tub.

Econo Lodge Buffalo offers free continental breakfast, a copy/fax service, free internet access, and 43 comfortable rooms that all feature a plasma TV, refrigerator, coffee maker and microwave. The red roofed, exterior corridor motel sits along the main road into town from the east (US 16), close to a selection of restaurants, gas stations and small shops, and a short distance from interstates 25 & 90. Rates are low, and the rooms are generally clean.

Although facilities are basic (just free coffee, cable TV and guest laundry), Buffalo's Motel 6 has a good reputation, on account of its low rates, clean rooms, helpful staff and peaceful setting, in the countryside on the east edge of town between I-25 and I-90. Unlike most properties of this brand, the hotel is a modern, interior corridor building whose rooms have nice views across the plains towards the distant Bighorn Mountains. There is a gas station opposite and a few restaurants nearby, though most facilities in Buffalo are between 1 and 2 miles west.