Santa Fe's Holiday Inn hotel has 130 rooms on 4 floors and is located on the south side of Cerrillos Rd (4048), 3 miles from interstate 25 and 6 miles from the historic Plaza district. This part of the city is mostly residential though just to the south, on the far side of Rodeo Rd, is the Santa Fe Place mall, and there are several large stores a short distance to the east. The Holiday Inn includes a bar/lounge/restaurant, a pool which is half indoor and half outdoor, and 3,300 square feet of meetings space.

Holiday Inn Express Santa Fe is one of many hotels along Cerrillos Road, the main route into town from Albuquerque and the southwest, and is about half way between I-25 and the downtown area. The 76 rooms are newly renovated, include a microwave and refrigerator, and some have views of the distant Sangre de Cristo Mountains. Hotel facilities include an outdoor pool and breakfast bar.

The adobe design of Courtyard Santa Fe helps create a typically Southwestern ambience, enhanced by tropical plants, cool walkways and open patio areas. The hotel is situated 3.5 miles from interstate 25 and 5 miles from downtown Santa Fe, along the busy Cerrillos Rd, though the 212 large rooms all face away from the highway and offer a quiet night's stay. On site is a restaurant/bar (Cafe Santa Fe, serving breakfast & dinner), an indoor pool and whirlpool. The Courtyard has some of the better meeting facilities in Santa Fe, with 6 rooms totaling over 6,500 sq ft of event space.

Located right next to the Santa Fe Place mall (main stores being JC Penney, Dillard's, Sears & Mervyn's), Fairfield Inn Santa Fe is another Southwest-style building along Cerrillos Rd, about 6 miles from the town center but well served by the local bus network. Exit 278 of I-25 is 2.5 miles away. Also nearby are many restaurants, and other shops including Target. The inn provides mid range accommodation in 56 comfortable rooms, with the two main amenities of free continental breakfast and an indoor pool.

In a hilly, residential district 1.5 miles south of Santa Fe town center, the all-suite Residence Inn by Marriott appeals to extended stay guests or those traveling in large groups, though is also well suited to short visits. The hotel has a quiet location surrounded by trees and lawns, next to the St Vincent Regional Medical Center and close to the junction of St Francis Drive with Highway 466. Its rooms all have a spacious living area with fireplace, an extra sofa bed, large work desk, separate sleeping area, and a full kitchen - purchase of food for which can be arranged by the hotel. For relaxation the Residence Inn offers an exercise room, hot tub and outdoor heated pool; other benefits of staying here are a free hot breakfast and free drinks & snacks at the evening social hour.

Like most hotels in Santa Fe, the Quality Inn lies along the Turquoise Trail (NM 14, Cerrillos Rd), the western approach to town, which links with exit 278 of I-25. This is a commercial neighborhood with plenty of restaurants and shops, including the Santa Fe Place Mall, 1 mile southwest. The hotel occupies quite a large site, with 98 rooms, an outdoor heated pool, sundeck and on-site restaurant; other amenities are a fitness center, airport shuttle and free full breakfast.

On the south side of the Turquoise Trail (Highway 14), the 3 floor Comfort Suites Santa Fe is a well regarded, all-suite hotel, receiving good reviews for its comfortable rooms, reasonable rates and helpful staff. The building is set back about 300 feet from the main road so ensuring a quiet night's sleep in all of the 60 suites and it has the traditional pinkish adobe design with Southwest decor in the rooms and public areas - which include an indoor pool, hot tub and a dining area where free full breakfast is served. There are half a dozen restaurants one block away, around the junction with Richards Avenue.

The 83 room Comfort Inn of Santa Fe is near the southwestern edge of the city, at 4312 Cerrillos Rd; 1.6 miles from I-25 exit 278 and 7 miles from the historic downtown area. There are many restaurants within easy walking distance of the hotel, and the largest mall in north New Mexico (Santa Fe Place) is one block away. Leisure facilities are an indoor pool, whirlpool, exercise room and children's playground.

The adobe style Best Western Inn of Santa Fe offers 97 rooms on 3 floors, located at 3650 Cerrillos Rd, on the south side of the highway. The center of old Santa Fe is an easy 5 mile drive away, the airport is 4 miles west and at least 8 restaurants are found within half a mile. The hotel has an indoor pool and serves free continental breakfast.

Another of the long line of hotels on the southwestern approach to Santa Fe (Cerrillos Rd), the Econo Lodge is a fairly new property that charges generally low rates yet provides good facilities: for leisure there is an indoor pool, hot tub & sauna, a free full breakfast is provided, some rooms are equipped with microwave/refrigerator, and the rooms are generally clean & comfortable. Downtown Santa Fe and the Plaza are 5 miles to the northwest.