Open late 2007, the brand new Holiday Inn hotel in east Las Vegas offers guests 115 beautifully-appointed rooms and a range of modern amenities. The hotel is built alongside the Boulder Highway in a lightly-developed neighborhood 2 miles north of Henderson town center, and 10 miles from downtown Las Vegas. There are a few convenience stores nearby, plenty of restaurants and several casinos; for more serious shopping the nearest center is the Galleria Mall, 2.3 miles west. Facilities at the Holiday Inn comprise a cafe open for breakfast & dinner (room service available), a lounge/bar, outdoor pool, fitness center, meeting rooms, and guest laundry.

The Holiday Express hotel in Henderson, NV, is a large, modern building (101 rooms & suites) with an even larger carpark, located at 441 Astaire Dr, along Warm Springs Road 2/3 mile west of I-215/US 95/US 93 between exits 62 and 64. The hotel is quite centrally located in the greater Las Vegas area; downtown Henderson is a few miles away to the southeast while Las Vegas International Airport is 8 miles west. One nearby attraction is the Galleria at Sunset mall, a block north along N Stephanie St. Holiday Express Henderson has an outdoor pool, whirlpool, bbq grills, health/fitness center, free breakfast bar, and several family-oriented KidSuites in addition to regular suites.

At the edge of an extensive residential area around the Wildhorse Golf Club, the Courtyard Las Vegas Henderson/Green Valley is approximately half way between The Strip and downtown Henderson, and also quite close to Las Vegas International Airport (5 miles away, served by complimentary shuttle). The hotel is located on the northeast corner of the intersection of N Green Valley Pkwy with E Sunset Rd, opposite various restaurants and shops including Albertson's. At the rear, hidden from the road, is a beautiful courtyard garden area with outdoor pool, hot tub, and plenty of palm trees; inside, the 155 rooms are clean and modern, as expected. There is a restaurant on site for breakfast (not complimentary).

The Residence Inn Las Vegas Henderson (2190 Olympic Ave) operates a free shuttle to The Strip and Las Vegas International Airport, putting guests within easy reach of the main attractions in town. In the other direction, Lake Mead and the Hoover Dam are less than a half hour drive away. The hotel has a quiet location next to another Marriott property (the Courtyard), though it is just a few minutes walk from a shopping center with plenty of restaurants. The all suite hotel caters for guests in 126 oversized rooms featuring a full kitchen, and provides both free full breakfast and a free evening light dinner (Mon-Thu). Leisure facilities are an outdoor pool, hot tub, sports court, and a bbq area in the courtyard garden.

The new TownePlace Suites by Marriott accommodates extended stay guests in 112 studio, one-bedroom and two-bedroom suites, all with separate living/sleeping areas and a full kitchen. The property sits at the south edge of Las Vegas/Henderson, near the mountain foothills but with good transport connections to all sites via the 215 Freeway which runs past just to the north: the hotel is 9 miles from the international airport, 12 miles from the Strip and 3 miles from the center of Henderson. The immediate surroundings are largely residential, through there are a selection of shops and restaurants nearby, at the junction of Stephanie St and Paseo Verde Parkway. The TownePlace Suites opened spring 2009.

One of two new all-suite Marriott hotels to open in Henderson in 2009, the four storey SpringHill Suites offers affordable, comfortable accommodation in 120 spacious studio suites featuring a pantry (sink, refrigerator, microwave), executive desk, free internet access and LCD TV. Both deluxe continental breakfast and evening reception are provided free of charge, and there are plenty of restaurants nearby for other meals - the hotel is situated next to a shopping center by the Stephanie St exit of I-215, adjacent to the TownePlace Suites sister property. Also available at the SpringHill Suites are a fireplace lounge, lobby bar, exercise room, indoor pool/whirlpool, laundry, business center and a meeting room.

Recently built (2008) Comfort Inn & Suites Henderson has 127 large, beautifully clean rooms featuring a refrigerator, microwave, plasma TV and pillow top mattresses - part of a handsome new building on the north side of town, along a side road (Marks St) near to Galleria at Sunset Mall and many other large stores. Also within walking distance are the Sunset Station Casino, and numerous restaurants. For relaxation the hotel offers the usual outdoor pool, hot tub and fitness center, while for those here to work, facilities include free internet access, a business center and three meeting rooms. Free continental breakfast is available.