The newly opened (summer 2008) Holiday Inn Pueblo is an upscale, full service hotel on the north side of town next to I-25 exit 102, right at the edge of the countryside and overlooking Fountain Creek valley, but also within walking distance of a good selection of shopping and dining. There are many large stores nearby including a Super Wal-Mart, and Pueblo Mall is just 1.3 miles south. The 4 storey hotel offers 89 well appointed rooms & suites, the latter with kitchenette facilities. Guests can dine at the on site restaurant/lounge, open for breakfast, lunch, dinner & room service, or relax in the pool, hot tub & fitness center. Event facilities comprise 3 meeting rooms totaling 1,680 sq ft of space.

One of relatively few hotels in Pueblo actually in the town center, the Marriott is an older property but still provides high quality accommodation, excellent customer service and full service facilities. The 7 storey building has 163 rooms, all decorated in a bright, modern style; the top floor concierge level rooms have enhanced amenities. For dining the on-site restaurant/bar (Charlie B's) is open all day for breakfast, lunch, dinner & room service, while for relaxation the Marriott offers the usual indoor pool, hot tub and fitness center. The adjacent Pueblo Convention Center has 12 meeting rooms totaling nearly 24,000 sq ft of event space. The hotel is located one block west of I-25 exit 98B along W 1st St - a mile from downtown Pueblo, on the far side of the Arkansas River.

Pueblo's Best Western has a quiet location along a side street close to exit 102 of I-25, right at the north edge of town (7 miles from the center), within walking distance of at least a dozen restaurants and close to the main shopping district in the area - many large stores line the side of the interstate, as far south as Pueblo Mall (1.3 miles away). The best feature of the hotel is the free full breakfast, which includes hot items such as cooked to order omelettes. There are 59 rooms available, all containing microwave/refrigerator, coffee/tea maker and ironing facility. Leisure amenities are an indoor pool, hot tub, sauna, and exercise room.

The handsome new Cambria Suites in Pueblo opened summer 2008 at 150 S Santa Fe Ave, a few blocks away from the city center and the Arkansas Riverwalk. The hotel is a well managed, full service establishment with a coffee bar in the spacious atrium lobby, a restaurant/lounge open for breakfast & dinner, and a 24 hour store where snacks & drinks can be purchased. For even more dining choices, there are many more restaurants within half a mile. Accommodation comprises 105 modern suites, all equipped with two LCD TVs, a CD/DVD player, microwave, refrigerator and spa-style bath. Other guest amenities include a pool/hot tub, exercise room, sun deck, business center and two meeting rooms.

Although an older building, Clarion Inn Pueblo was remodeled in 2007, and it offers an above average range of facilities including a restaurant/lounge, large indoor pool, hot tub, games room, billiard/pool tables, an exercise room, sauna and guest laundry. Free full breakfast is served. The hotel's 117 exterior-corridor rooms are divided into two blocks, looking out over a busy commercial area by the US 50/I-25 junction, on the north side of town close to Pueblo Mall and various other large stores. Some of the rooms have extra amenities like a microwave, refrigerator and pull-out sofa bed. The Clarion is a good meeting venue - there are 4 rooms, and the largest can accommodate reception events up to 260 guests.

Another of the hotels near exit 102 of I-25 on the north side of Pueblo, the Comfort Inn is small, clean, quiet, reasonably priced, and within a short walk or drive of many restaurants & shops. There are 60 rooms in the 2 storey building, some equipped with microwave, refrigerator & whirlpool bath. Other interior facilities are a rather small pool, guest laundry, an internet-enabled computer in the lobby, and a dining room for the free continental breakfast.

The Econo Lodge motel in Pueblo stands opposite another Choice Hotels property (the Comfort Inn) on Elizabeth St, one block from exit 102 of Interstate 25. Rates are quite low but not at the expense of cleanliness, good customer service or facilities, which include free continental breakfast, a pool, hot tub, sun deck and guest laundry. All the 53 rooms contain a refrigerator; some have a microwave and/or whirlpool bath. As well as the many nearby shops and restaurants, the Econo Lodge is also close (3 miles) to Colorado State University-Pueblo.

Sleep Inn Pueblo is one of several hotels next to Pueblo Mall, on the north side of town, and it provides economically priced accommodation in 71 large rooms with amenities of free enhanced continental breakfast, an indoor pool, hot tub and guest laundry. Besides the mall and other nearby shops there are many restaurants within walking distance, and Pueblo Country Club is 2 miles west. A railway runs along the east side of the hotel hence the west-facing rooms are quieter.

Like most hotels in Pueblo, CO, the 62 room Quality Inn is located near the north edge of town, close to dining, entertainment and shopping including Pueblo Mall, though unlike other properties the hotel is a little way off I-25 (0.7 miles), along US 50 - a busy road but the hotel has a quiet setting 500 feet from the highway. South-facing rooms have views of the greens and fairways of Pueblo Country Club. Amenities are the standard complimentary continental breakfast, hot tub, pool and exercise room. Rooms are available with one or more of a microwave, refrigerator, whirlpool bath and sofa bed.