The 5 floor Holiday Inn Palmdale is a full service hotel at the edge of the Mojave Desert and by the foothills of the San Gabriel Mountains, just east of highway 14 along W Palmdale Blvd. The center of Palmdale is a mile east, and the larger town of Lancaster is 10 miles north. The handsome, modern, 148 room hotel lies next to a residential district but close to attractions such as the Antelope Valley Mall, Desert Sands Park and Antelope Valley Country Club; its many amenities include the on-site Skyview Terrace restaurant, a cocktail lounge, outdoor pool, whirlpool, fitness center, and a range of facilities for business & events.

Right next to the Holiday Inn stands a new sister property, Staybridge Suites Palmdale (open 2008), which caters more for the long stay traveler in 99 comfortable, non-smoking suites that feature a microwave, full refrigerator, large work desk and separate living/sleeping areas. Both free full breakfast and free evening reception are provided; for other meals the nearby main road (W Palmdale Blvd) has a few restaurants within walking distance. Leisure amenities comprise a sports court, outdoor pool, hot tub and fitness center. A complimentary shuttle is available to places within 5 miles, including Antelope Valley Mall and the center of Palmdale.

Towards the north side of Palmdale, CA, Marriott's Courtyard hotel is a typically clean, comfortable and well managed place, offering 90 rooms and suites in a new-looking 3 floor building alongside Highway 14/138, the Rancho Vista Blvd exit. The hotel is within a mile of many large stores including those at the Antelope Valley Mall, and half a mile from the golf course at Antelope Valley Country Club. The on site Courtyard Cafe serves freshly cooked breakfast, while drinks & snacks are available at the evening receptions (Mon to Sat). Other amenities include an indoor pool, hot tub and fitness center.

Like most hotels of this brand, Residence Inn Palmdale is situated right next to another Marriott property, in this case the Courtyard - the two hotels face each other at the end of a short side road off Rancho Vista Blvd (W Avenue P), just east of exit 37 of Highway 14/138. The inn is regarded by many as the best of the small but generally good quality selection of lodging in Palmdale, on account of its excellent customer service, convenient location near to shopping & dining, but especially the size, facilities and cleanliness of the rooms. Accommodation comprises 90 suites, each with a full kitchen plus separate areas for living, working and sleeping. Complimentary buffet breakfast and evening reception are provided, while for relaxation the residents can take advantage of an indoor pool, whirlpool and fitness center.

One of several hotels spread out along W Palmdale Boulevard, separated by patches of undeveloped land, the new Best Western John Jay Inn & Suites offers 63 rooms, free continental breakfast, an exercise room, heated outdoor pool, spa and sauna. All 63 rooms contain a microwave & refrigerator, ironing and coffee making facilities, and benefit from free high speed internet access. The inn is 0.8 miles west of exit 24 of highway 14, and a further mile from downtown Palmdale. The best choice of restaurants nearby is a mile north on 10th St, around Antelope Valley Mall.