The largest hotel in Casa Grande, AZ, and the only full service establishment near the town center, is the 176 room Holiday Inn, taking up most of one block by the busy intersection of highways 387, 287 and 84. The place was fully renovated after being acquired by the Holiday Inn chain in 2007, and is centered on a sizeable tropical garden with a pool, hot tub, sundeck, lawns and palm trees. The hotel has its own restaurant/bar/lounge, open for breakfast, lunch & dinner, and is close to plenty more restaurants along the main road across town (Florence Blvd). A complimentary 5 mile radius local area shuttle is provided. The main attraction in the region (Casa Grande Ruins National Monument) is 22 miles away to the northeast.

Best Western Casa Grande has a peaceful, countryside setting 2 miles east of the center of Casa Grande and just over a mile west of I-10 (exit 194); the hotel is surrounded by fields on 3 sides, while to the north, on the opposite side of Florence Boulevard, is the Casa Grande Regional Medical Center. The 80 room hotel is generally considered the best of the limited selection of lodging in Casa Grande on account of the quiet location, reasonable rates, good staff and the nice (free) breakfast. The main amenities are a fitness center, hot tub, bbq grills, and a heated outdoor pool set amid tree-shaded gardens. For lunch and dinner there is a Denny's restaurant adjacent.

The Comfort Inn hotel in Casa Grande is reached from exit 194 of I-10, just a short drive west along Florence Boulevard - the hotel is built on the south side of the road, surrounded by farmland. The main commercial and residential districts of Casa Grande are a few miles further west though there is a shopping center with a decent selection of restaurants one block east, and a golf club (Mission Royale) just the other side of the interstate. Rooms are large, clean and quiet, equipped with microwave & refrigerator, and have nice views over the countryside. The hotel provides all the expected amenities - free continental breakfast, outdoor heated pool, hot tub, newsstand, exercise room and guest laundry.

For extended stays in the Casa Grande area, or for those people needing extra space & facilities, the new MainStay Suites hotel at 851 N Henness Road offers large, well maintained suites with fully equipped kitchens and many other amenities. Henness Road is 1.3 miles east of exit 194 of I-10, part of a residential/rural area, 2 miles from the center of Casa Grande. The hotel serves basic free continental breakfast and has facilities of an exercise room & guest laundry, though no pool. Room rates are quite low.