Click on a city for hotel listings, or a hotel for reservations. The hotels featured are either right beside the interstate exit or at most half a mile from it. I-2 in far south Texas was established in 2013, along a 46 mile stretch of US 83, from Harlingen in the east to Penitas in the west.

All Texas interstates: I-2, I-10, I-20, I-27, I-30, I-35, I-35E, I-35W, I-37, I-40, I-44, I-45.

Please refer to the disclosure notice for information about the affiliate (commissionable) links on this page.

Exit	Roads	City	Hotels
	US 83 west	Penitas
130	Showers Road
131	FM 492 (Goodwin Road), Abram Road	Palmview
133	SH 364 (La Homa Road), Bentsen Palm Drive	Palmview
134	Bus US 83, Inspiration Road	Mission
135	Los Ebanos Road	Mission
136	SH 107, FM 1016 (Conway Avenue)	Mission
137	FM 396 (Bryan Road, Anzalduas Highway)	Mission	★★★★★ SureStay Hotel Mission
138	Shary Road	Mission	★★★★★ Hampton Inn & Suites Mission ★★★★★ Holiday Inn Express Hotel & Suites Mission-McAllen Area
140	FM 2220 (Ware Road)	McAllen	★★★★★ Embassy Suites by Hilton McAllen Convention Center ★★★★★ Homewood Suites by Hilton McAllen ★★★★★ SpringHill Suites McAllen ★★★★★ Cambria Hotel & Suites McAllen Convention Center ★★★★★ Hawthorn Extended Stay by Wyndham By Wyndham McAllen
141	Hwy 115 (23rd Street)	McAllen
142	SH 336 (10th Street)	McAllen	★★★★★ DoubleTree Suites by Hilton Hotel McAllen ★★★★★ Radisson Hotel McAllen Airport ★★★★★ Courtyard McAllen Airport ★★★★★ Residence Inn McAllen ★★★★★ Staybridge Suites McAllen ★★★★★ Hilton Garden Inn McAllen ★★★★★ Clarion Inn McAllen ★★★★★ Holiday Inn Express & Suites McAllen - Medical Center Area ★★★★★ Fairfield Inn & Suites McAllen Airport ★★★★★ Comfort Suites McAllen ★★★★★ Days Inn by Wyndham McAllen ★★★★★ Super 8 McAllen/Downtown/La Plaza Mall
143A	McColl Road, 2nd Street	McAllen	★★★★★ Holiday Inn McAllen-Medical Center Area ★★★★★ Hampton Inn & Suites-McAllen ★★★★★ Best Western Rose Garden Inn and Suites ★★★★★ Baymont by Wyndham McAllen
143B	Jackson Avenue, Sam Houston Boulevard	Pharr
144	Bus US 83 (Center Avenue), FM 2061, FM 3362 (Jackson Road)	McAllen, Pharr
145	Sugar Road, Polk Avenue	Pharr
146	I-69C, US 281	Pharr
146C	Frontage Road	Pharr
147A	Veterans Boulevard	Pharr, San Juan	★★★★★ Rodeway Inn San Juan
147B	FM 1426	San Juan	★★★★★ Home2 Suites by Hilton San Juan
149	FM 2557 (Stewart Road), Cesar Chavez Road	San Juan
150A	FM 907 (Alamo Road)	Alamo
150B	Tower Road	Alamo
152	FM 1423 (Val Verde Road)	Donna
153	Hutto Road	Donna
154	Spur 433 (Main Street)	Donna	★★★★★ Comfort Inn & Suites Donna
155A	FM 493 (Salinas Boulevard, Donna Boulevard)	Donna
155B	Victoria Road, Midway Road
157	Westgate Drive, Mile 6 W Road	Weslaco	★★★★★ Hampton Inn Weslaco ★★★★★ Best Western Town Center Inn
158	FM 88 (Texas Boulevard)	Weslaco
159	Airport Drive, Pike Boulevard	Weslaco	★★★★★ Super 8 by Wyndham Weslaco
160	FM 1015 (International Boulevard)	Weslaco	★★★★★ Holiday Inn Express Hotel & Suites Weslaco
161	Spur 31 (Mile 2 W Road)	Mercedes
163A	Vermont Avenue	Mercedes
163B	FM 491 (Texas Avenue)	Mercedes
164	Mile 1 E Road	Mercedes	★★★★★ Quality Inn & Suites Mercedes
165	FM 1425 (Mile 2 E Road)	Mercedes
166	Mile 3 E Road	Mercedes
167	FM 2556 (Solis Road, Cantu Road)	La Feria
168	Rabb Road	La Feria
169	FM 506 (Main Street)	La Feria
170	FM 733 (Kansas City Road), White Ranch Road
171	FM 800 (Bass Boulevard)	Harlingen
172	Altas Palmas Road	Harlingen
173	FM 3195 (Stuart Place Road)	Harlingen
174	Bus US 83, Lewis Lane	Harlingen
175	Tyler Avenue (Spur 206), Dixieland Road	Harlingen
176	I-69E, US 77	Harlingen	★★★★★ Courtyard Harlingen ★★★★★ Residence Inn Harlingen ★★★★★ Holiday Inn Express Harlingen ★★★★★ Quality Inn Harlingen ★★★★★ Super 8 by Wyndham Harlingen