The mountains provide a backdrop for Hwy 376
, from Austin - this runs for over 50 miles along Big Smoky Valley, as the peaks rise over 6,000 feet above. The main access to the wilderness from this road is from North Twin and South Twin Creek trailheads, at the mouths of two valleys, from where paths climb towards the crest. The other most used entrance point is at Columbine Campground in the north, along a track (NF 119) from Hwy 21, itself an unpaved route, along the upper end of the Reese River Valley, on the west side of the hills, where the land is less steeply-sloping. The trail from here follows one of the many streams, Stewart Creek, into the hills, then ascends more steeply to a ridge and continues to the summit of Arc Dome, after 8 miles, linking with several other routes along the way. Lesser used trailheads are situated in the west at Cow Canyon, the southwest at Weeks Canyon, the south at Toms Canyon and in the southeast at Jett Canyon. The 63 mile Toiyabe Crest Trail enters the wilderness from the north at Ophir Summit, loops around three sides of Arc Dome then descends northeastwards, terminating at the South Twin trailhead.