Like most hotels in Rock Springs, the Holiday Inn is located near the busy US 30/I-80 intersection on the west edge of town, part of a sizeable area of restaurants, shops and other traveler facilities, centered on White Mountain Mall. Guests enter the hotel through a particularly elegant lobby complete with water fountain, and benefit from a wide range of full service amenities. The adjacent restaurant (Winger's) is open for breakfast, lunch, dinner and room service, with drinks available in the attached sports bar. For leisure the Holiday Inn has an indoor salt water pool (open 24 hours), a hot tub and a well equipped fitness center. Event facilities are comprehensive, comprising nearly 10,000 sq ft of space, enough for single groups of up to 400 people. The 170 guest rooms (on 4 floors) are very clean and comfortable, and all have a refrigerator & microwave.

A brand new Holiday Inn Express hotel in Rock Springs opens early 2010, next to I-80 at the US 30 junction (exit 102; Dewar Drive), and directly opposite the Holiday Inn sister property. There are many restaurants and shops within walking distance, including Wal-Mart, though the hotel backs on to undeveloped land bordering a small river (Bitter Creek). Facilities are free hot breakfast buffet, 24 hour indoor pool & fitness center, bbq grills, hot tub, laundry, business center and one meeting room. The 79 rooms & suites all have a DVD player, refrigerator and microwave.

Best Western Outlaw Inn has 101 clean and comfortable rooms, accessed by interior corridors around the edge of an enclosed central courtyard that contains a good sized indoor pool. The building is quite old but has been maintained well, and the hotel has a decent range of facilities including its own restaurant & lounge (with room service). Also available are free internet access, business services, and meeting/banquet space. The hotel is located along Elk St (US 191) on the north edge of town, just off interstate 80.

Open 2009, Comfort Inn & Suites Rock Springs provides spacious, mid range accommodation at reasonable rates together with all necessary facilities: free continental breakfast and free internet access, an indoor pool/whirlpool, business center and laundry. The 57 rooms are on three floors of an attractive, compact building on a side road off Foothill Blvd, which leads to White Mountain Mall two blocks west; there are many other shops and restaurants nearby, either side of interstate 80. The main natural attraction in the area (Flaming Gorge NRA) begins 35 miles south along Hwy 530.

Although the Quality Inn is one of the older hotels in Rock Springs, it has spacious and updated accommodations, charges quite low rates, and has plenty of amenities. Most of the 103 rooms are on the ground floor, arranged around three sides of the central courtyard/parking area, in the middle of which is an outdoor pool, hot tub, garden, sundeck and childrens' playground. Free continental breakfast is provided each morning, and a free manager's reception in the evenings; there is no shortage of restaurants nearby to provide other meals. Interior facilities include a fitness center, gift shop, laundry and newsstand.

Rooms at the Econo Lodge are some of the most affordable in Rock Springs, yet the hotel still offers all the basic facilities, of free continental breakfast, free internet access, a pool & hot tub, and business services. Some of the 98 exterior corridor rooms (on 2 floors) have a refrigerator and microwave. Pets are welcome, for a small fee. The hotel is part of a line of small shops and restaurants on the north side of the city one block from I-80 and 4 miles from the main shopping area in town, around White Mountain Mall.