Generally considered the best of the small number of chain hotels in Jackson, Best Western The Lodge is a large, Western-style building on a quiet side road just off US 26/89/189/191 one mile west of the city center and one block from a shopping district with several restaurants. Many of the 153 refrigerator/microwave-equipped rooms & suites have nice views south to the wooded slopes of Snow King Mountain, to northwards towards Gros Ventre Butte, behind which lies the Teton Range; the national park entrance is just 11 miles away. Hotel highlights include a two-floor fireplace lobby, free hot breakfast, a lounge/bar, fitness center, pool, hot tub and sauna.

The Quality Inn hotel in Jackson, WY, occupies one block in a quiet, residential district near the town center - less than half a mile from Town Square and so close to many restaurants, shops and art galleries. Guests have a choice of 142 rooms - large, clean and reasonably priced; also available are a number of suites with one or more of a microwave, refrigerator, fireplace and whirlpool bath. Free continental breakfast is provided, and the adjacent Chili Pepper restaurant/lounge is open all day for other meals, and evening drinks. The hotel has no pool, but there are two hot tubs, a sauna and a fitness center.

The Motel 6 is one of the first hotels to greet travelers arriving in Jackson from the south, and it provides some of the lowest-priced lodging in town, while still being clean, welcoming and conveniently located near to shopping & dining. Facilities are limited to wi-fi, laundry, cable TV, free coffee, and a small outdoor pool set in the middle of a courtyard garden at the center of the property. Downtown Jackson is 2 miles east along the main road, with Grand Teton National Park ten miles further.