At 950 N Grand Canyon Boulevard, the full service Holiday Inn hotel in Williams is situated right at the north edge of town, adjacent to exit 163 of I-40, half a mile from the downtown area around old Route 66 (Railroad Ave) and just a short walk away from undeveloped woodland. The clean and well maintained property offers 120 rooms on 2 floors, an indoor pool, guest laundry, convenience store/gift shop, and the Doc Holliday Steakhouse restaurant. The hotel is an easy 56 mile drive from the Grand Canyon, 33 miles west of Flagstaff, and half a mile from the terminus of the Grand Canyon Railway.

The Best Western is the first hotel in Williams for travelers arriving from the west - at 2600 W Route 66, just beside interstate 40 (exit 161, Bill Williams Ave). The inn sits amongst ponderosa pine trees at the edge of the forested foothills of Bill Williams Mountain, which rises to 9,256 feet a few miles to the south. The hotel has 79 rooms, a heated outdoor pool, spa, gift shop selling Southwest souvenirs, and a dining area where good quality (free) continental breakfast is served. The center of Williams is one mile west, putting guests within easy walking distance of various restaurants and shops.

The Fairfield Inn of Williams has a woodland location along a short spur road on the north side of I-40 (exit 163), next to the Holiday Inn. Old Route 66 and Williams town center are within walking distance, 0.7 miles south along N Grand Canyon Blvd, though there are plenty of restaurants much closer, either side of the interstate. A heated outdoor pool and free continental breakfast are two the main amenities of the inn, which has 80 comfortable rooms, all with coffee maker & ironing facilities.

The Quality Inn Resort lies some 8 miles east of Williams - 6701 E Mountain Ranch Rd, which is just south of exit 171 of interstate 40. The resort is the only building on this road, and has a peaceful country setting, bordered to the south by pine woodland of the Kaibab National Forest, with hiking trails starting right from the hotel and views of the San Francisco Peaks to the northeast. This is quite a well equipped hotel with a fitness center, gift shop, outdoor pool (seasonal), tennis courts and on-site restaurant. There are 73 rooms, in the familiar motel-style layout of 2 floors and exterior corridors.

Recently acquired by the Rodeway Inn chain, the Downtowner Motel is regarded by many as the best place to stay in Williams, Arizona. It has a central location (201 E Route 66), newly redecorated rooms including plasma TVs & granite work surfaces, welcoming staff, and a wide choice of items in the free continental breakfast. Some rooms are available with a microwave, refrigerator and whirlpool bath. The property dates from the 1950s and retains some of the style and decor from that bygone age. A little further down the road is the similarly named Rodeway Inn Williams at Route 66; here the lodging is rather basic, though cheap.

Like most hotels in Williams, the Comfort Inn (formerly Grand Canyon Country Inn) sits along historic Route 66 - at the west end of town next to a supermarket, and a short walk from several restaurants. Rooms are fairly basic but modern, equipped with flat screen TV; some have a microwave and refrigerator, and those on the west side enjoy peaceful views across a field towards wooded hills. Free continental breakfast, free internet access, an indoor pool/hot tub, laundry and a business center are the other main facilities.

One of many budget motels along old Route 66 right in the center of Williams (at 302 E), the Econo Lodge has 2 floors and 40 rooms - small but clean, remodeled in 2007 and quite comfortable - and an quick walk away from all the shops, restaurants, bars & art galleries in town. Staff are friendly, knowledgeable of the area, and can assist with arranging local excursions. The one main amenity is free continental breakfast.