Most rooms at the newly built (2008) Holiday Inn Express Hotel & Suites Willcox have long distance views over the undeveloped surroundings, on the west side of interstate 10 by exit 340 - 35 miles from the main natural attraction in the area, Chiricahua National Monument. All accommodation and the public areas are very clean & modern, and the hotel has a good range of facilities, principally free breakfast (including a few hot items), free internet access, a fitness center, outdoor pool, newsstand and business center. The nearest restaurants are about half a mile away, along Rex Allen Drive on the far side of the interstate. Besides the regular rooms, several suites are available with a microwave, refrigerator, and divided living/sleeping areas.

The Best Western Plaza Inn of Willcox looks out over the desert on the north side of town - the hotel is built next to exit 340 of I-10 (W Rex Allen Drive), though set back a little from the main road, and so provides generally quiet accommodation. The downtown area is a mile south. This is a 91 room, exterior corridor inn - the only full service hotel in Willcox - and it offers a heated outdoor pool, on-site American restaurant (open for breakfast & dinner), cocktail lounge, guest laundry, business center, and meetings/event space for up to 200. Breakfast (continental) is provided free of charge.

Motel 6 Willcox is a medium sized, low price property with amenities of an outdoor pool, guest laundry and free coffee in the lobby. The small but clean rooms are on two exterior corridor floors, and look out over a neighborhood of shops, restaurants and gas stations beside I-10 on the north side of town, along Rex Allen Drive (exit 340).