The Holiday Inn Express Hotel & Suites is 2 miles northwest of the center of Nogales, in a quiet, partly rural area, though still close to I-19 - the hotel is reached from exit 4, turning left along W Mariposa Road then right along N Frank Reed Road. The Holiday Inn has 99 oversized rooms and 20 suites over 3 floors, a fitness center, outdoor pool, convenience store, gift shop and a recreation court.

Extended stay visitors to Nogales are well served by the new Candlewood Suites hotel (875 N Frank Reed Rd) - an all suite, 83 room property built in a quiet, hilly area on the north side of town, just off interstate 19 - access is from exit 4. The suites all have a full kitchen (microwave, stove, dishwasher, refrigerator), plus an extra sofa bed, DVD player and large work desk. There are various shops and fast food restaurants nearby, along Mariposa Rd, with plenty more choices in the center of Nogales 2 miles south. Other facilities at the hotel are a 24-hour market, fitness center, gift shop, pool and hot tub.

One mile from Mexico along the Nogales-Tucson Highway, the Best Western Siesta Motel is near the center of Nogales and so close to many restaurants, shops and local attractions. The hotel has 46 rooms arranged around 3-sides of a courtyard, with a large outdoor pool at one side, and offers free breakfast. Other dining is available from Denny's restaurant, directly adjacent to the hotel.

Formerly the Americana Motel, the new Quality Inn hotel in Nogales is one of a number of properties along Grand Avenue in the town center (next to the Best Western), one mile from the Mexican border. Rates are fairly low and facilities quite basic - just guest laundry, an exercise room and an outdoor pool, this latter in a secluded courtyard at the center. There are 97 interior corridor rooms available, some with a sofa sleeper, microwave and refrigerator. For dining the adjacent Mexican restaurant is open for breakfast, lunch & dinner.

Right opposite the main shopping area in town (Mariposa Mall) along Grand Avenue, Motel 6 Nogales is a budget-priced, exterior corridor property with small but clean rooms, free coffee in the lobby, an outdoor pool, guest laundry and free wi-fi. Some rooms are available with a microwave and a refrigerator. There are many restaurants within walking distance, and the border with Mexico is 2.8 miles south.