Plainview's Holiday Inn Express hotel opened in 2005, built on the west edge of town just northwest of exit 49 of I-27 (Olton Rd; US 70) - next to the Wal-Mart and JC Penney stores. The 3 storey hotel has 43 rooms and 19 suites, most having views over flat farmland though there are various restaurants and other shops in the vicinity. For leisure, the Holiday Inn offers an indoor pool, whirlpool, and health & fitness center.

The Best Western hotel in Plainview, Texas, has 75 rooms on 2 floors, an outdoor pool and free continental breakfast. The inn is just southeast of the junction of US 70 (Olton Rd) and I-27 (exit 49), on the east edge of Plainview - part of an area of shops, restaurants and motels on both sides of the interstate, in an otherwise rural/residential neighborhood. Also nearby is Plainview Country Club, half a mile southeast. The red cliffs and valleys of Caprock Canyons State Park are 45 miles to the east.

Comfort Suites Plainview is located at 3615 Grandview Drive, one block southeast of exit 49 of I-27, and 2.5 miles west of downtown Plainview. This is a 2 floor, all-suite hotel that also contains a business center, indoor pool & hot tub, fitness center and breakfast bar, and has a microwave & refrigerator in each room. For dining there are at least 6 restaurants within walking distance.