The Holiday Inn Express is both the newest and the most northerly hotel in Pampa - at 3119 Perryton Pkwy (TX 70), the 70 room/suite property is right at the edge of town, on the west side of the highway next to Pampa Regional Medical Center. Pampa town center is 3 miles away, and this is the best place for restaurants, though the hotel does provide complimentary continental breakfast. The hotel also offers an indoor pool/whirlpool, fitness center and business center.

On the north edge of Pampa along TX 70 (2831 Perryton Pkwy), the Best Western Northgate Inn has 100 rooms on 2 floors, with exterior corridors. Some rooms overlook the outdoor pool and gardens, others have views over the mostly rural land that surrounds the hotel, though the inn is just 0.1 miles from 2 major sites; the Regional Medical center to the north, and Pampa Mall to the south. Other chief amenities are free continental breakfast, sundeck, guest laundry and an on-site restaurant - Family Steak House.