Holiday Inn Express Moriaty, at 1507 E Route 66 (Central Ave), is an east-west facing building close to exit 194 of I-40, 2 blocks from the western edge of town and the start of the arid grasslands that stretch for 15 miles to the edge of the Manzano and Sandia Mountains. The 70 rooms have coffee maker, ironing board and 25" satellite TV, while the hotel offers an indoor pool/whirlpool, covered patio, games room and breakfast bar.

Like most hotels in Moriarty, the 68 room Comfort Inn is located along Central Avenue (former Route 66), which runs for 3 miles parallel to interstate 40 between exits 194 and 197, though the closest exit is 196, Howard Cavasos Blvd; the hotel is 2 blocks south, at the center of town. There are many restaurants nearby, and several convenience stores. Chief amenities are an indoor heated pool and free breakfast.