The newest hotel in Yreka, open 2008, is the Holiday Inn Express, which is built in the countryside a short distance east of I-5 exit 776 (at 707 Montague Rd), so all the 68 rooms & suites are quiet and have relaxing views over the surrounding fields and wooded hills, but the place is still just within walking distance (one mile) of shops, restaurants & historic buildings in downtown Yreka. The 3 floor hotel is clean and welcoming, and provides all the usual Holiday Inn Express amenities, including free continental breakfast, a pool (indoor), fitness center, business center, meeting room and guest laundry.

Right at the center of Yreka, CA, along historic Miners St (just east of the junction with Main St), the Best Western Miner's Inn offers 130 rooms and apartment suites, an outdoor pool, on-site restaurant and a conference center accommodating up to 250 guests. The hotel is next to I-5 exit 775, though sheltered from the highway by a belt of trees, and is within easy walking distance of all necessary facilities in downtown Yreka. Free continental breakfast is served. Natural attractions in this part of north California include Mount Shasta, 45 miles south and the Lava Beds National Monument 70 miles east (partly on unpaved roads).

Rodeway Inn Yreka has 41 rooms all on the ground floor - a traditional, small, roadside motel but one that presents an attractive option for budget travelers, with friendly staff, a fairly quiet location, and all the standard facilities - free continental breakfast, outdoor pool, fitness room and hot tub. All the rooms have a microwave and a refrigerator. There are several restaurants adjacent or opposite, and more 2 blocks south along Main St, while for shopping, the few large stores in town are one mile further south, next to I-5 exit 773.

Yreka's Econo Lodge motel has a south central location at 526 S Main St, close to exit 775 of I-5, adjacent to at least 6 restaurants and half a mile from the College of the Siskiyous. Some of the 44 rooms have views over the slopes of Butcher Hill to the east, others overlook the central courtyard/parking area and outdoor pool (seasonal). All rooms have a microwave & refrigerator, and the hotel serves free continental breakfast.

Comfort Inn Yreka is situated 2 miles south of the town center at 1804 Fort Jones Rd (highway 3), in a generally rural location, yet close to a selection of restaurants, gas stations and several large stores including a Wal-Mart. Exit 773 of I-5 is just to the north. The hotel is an older property but well managed, with 3 floors, 50 rooms (containing microwave/refrigerator), an outdoor pool and free continental breakfast. One mile west, Greenhorn Park has a picnic area, footpaths, a children's playground and a display of old mining equipment.