Ukiah is exactly half way - 115 miles - between San Francisco and the first of the large redwood groves of north California (the Humboldt Redwoods), so makes a good place to stop for a night and break the journey. The Holiday Inn Express is right next to the State Street exit of US 101 on the north side of town, about 1.5 miles from the center where most of the best restaurants are located; it has the expected amenities of free continental breakfast, fitness center, hot tub & outdoor pool, but also a sports court and newsstand.

The 54 spacious rooms of the Best Western Orchard Inn look out over a mixed residential/commercial district on the east side of Ukiah, alongside Highway 101 (close to the Gobbi St exit) and just a short drive away from many vineyards of the upper Russian River Valley. All necessary amenities can be found within half a mile including a shopping center and a selection of restaurants. The hotel has an outdoor pool/hot tub, an exercise room & guest laundry; the standard free continental breakfast is available

Although quite recently opened (2007), Comfort Inn Ukiah is regarded by many as the top hotel in town, on account of its excellent customer service, the good quality free full breakfast, and the clean & modern rooms, all of which have a microwave, refrigerator, and some benefit from a balcony & extra sofa bed. The hotel is built along a shopping street one block from US 101 on the south side of Ukiah, and near the local airport. There are many restaurants close by. The other main facilities of the Comfort Inn are an outdoor pool, newsstand, one meeting room and guest laundry.

The Fairfield Inn of Ukiah, CA, has an easily reached location towards the south end of town, 2 blocks from Highway 101, with a shopping center on one side and the municipal airport on the other. It is quite a compact place, containing 12 suites and 44 rooms, all with a good range of amenities that includes a microwave & refrigerator. The clean, new hotel also offers an indoor pool, Jacuzzi, exercise room, guest laundry, and a dining area for the free continental breakfast. For other meals, the local road (Airport Park Blvd) has several restaurants, with others 0.5 miles away along State St.

Ukiah's Quality Inn motel is located a few blocks south of the town center at 1050 S State St, 0.5 miles west of Highway 101 along Talmange St and close to several restaurants including Denny's. This is a typical two floor property with exterior corridors, offering basic but comfortable accommodation, and amenities comprising free continental breakfast, an outdoor heated pool, guest laundry and some rooms with microwave & refrigerator.