Near the middle of Redwood City by the busy junction of highways 82 (El Camino Real) and 84, the Holiday Inn Express offers good value accommodation with friendly staff and 62 large, comfortable rooms linked by interior corridors. The main road passes plenty of fast food restaurants nearby, closest being Wendy's right next door, though free breakfast (continental) is available at the hotel. Leisure amenities are a whirlpool and an exercise room.

The southernmost of the two Holiday Inn Express hotels in Redwood City is about half way to the neighboring town of Menlo Park, and like most other hotels in this part of Silicon Valley it is located along Highway 82, El Camino Real. The building is quite small, containing 35 rooms on 2 floors, with exterior corridors - an older, motel design, but with modern amenities like a microwave & refrigerator in each room. The nearest restaurants are one block away to the north or south along the main road.

On 5th Avenue by the junction with El Camino Real, the Best Western Executive Suites in Redwood City has 29 one-bedroom, two-bedroom or Jacuzzi suites, all containing a microwave & refrigerator, and some with a full kitchen. The three main amenities are an exercise room, spa and free continental breakfast - in common with many hotels in this area there is no swimming pool. Restaurants within one block include Jack in the Box, Dominos Pizza and La Roca.

The 31 room Best Western Inn Redwood City lies towards the north side of town, a mile or so from the neighboring district of San Carlos and 24 miles south of downtown San Francisco. This is one of dozens of smallish hotels along Highway 82 through Silicon Valley that offer a generally similar standard of accommodation though in this case the amenities are above average, with an on-site restaurant, and a nice outdoor pool, located at the rear, away from the main road. The inn serves the familiar free continental breakfast.

Comfort Inn Redwood City is one of the more central hotels in town, at 1818 El Camino Real (next to the Holiday Inn Express Central), within 4 miles of the towns of Belmont, San Carlos, Atherton, Menlo Park and Palo Alto. The inn has 52 rooms, recently updated and all containing a microwave and refrigerator; some have a kitchenette and whirlpool bath. Also on offer are an outdoor pool and a sauna. Continental breakfast and afternoon tea are provided free of charge.

Although listed as being in Redwood City, the Towneplace Suites by Marriott hotel is closer to the neighboring town of San Carlos - located right next to San Carlos Airport, and also overlooking a large area of estuarine land at the edge of San Francisco Bay (Redwood Shores). The 95 suites feature separate sleeping/living sections, a full kitchen and an extra sofa bed, and are aimed primarily at the long stay and/or business traveler. Residents have use of a guest laundry, business center, fitness center and a hot tub. The nearby Redwood Shores Parkway has a fair selection of restaurants.