The Marriott is perhaps the most luxurious chain hotel in Napa, offering full service amenities combined with excellent customer service and a good location, in a quiet, mostly residential area on the north side of town alongside Highway 29 which leads through the middle of Napa Valley, passing many of its famous vineyards over the next 20 miles. The hotel is fairly old but received a major renovation in 2008, updating the decor and adding modern features such as flat screen TVs. Its 270 rooms & suites are spread over several two storey blocks arranged around a courtyard garden with outdoor pool. Other facilities include a restaurant/bar, cafe, business center, fitness center, hot tub and the Amadeus Spa & salon. The Marriott has particularly good facilities for meetings, with 12 separate rooms totaling over 20,000 sq ft of event space.

Generally rated as the top hotel in Napa, the Best Western Elm House Inn has a west-central location alongside Highway 29 (which leads northwards to the many local wineries), opposite Napa Premium Outlets Mall and half a mile from the historic town center. This is a small (22 room) boutique-style hotel with high quality service, decor and amenities, featuring a bright atrium lobby and a well kept garden that contains sculptures, a fountain and an outdoor spa. Complimentary deluxe continental breakfast is served between 7.30 and 10 am, while for lunch & dinner there are a few restaurants around the mall though most are in downtown, starting 10 blocks east.

Best Western Inn at the Vines is a 68 room hotel on the south side of Napa along Soscol Avenue (Highway 121), close to John F Kennedy Memorial Park and Napa Valley College, and it offers relatively cheap lodging in this rather expensive town. Facilities are still quite good, with an outdoor pool & spa, and free full breakfast served each morning (at the adjacent Denny's restaurant). The rooms are clean, newly re-furnished and equipped with microwave & refrigerator.

Marriott's most affordable all-suite brand opened a new property early 2009 on the south side of Napa - in a quiet location next to a business park just off the Napa Vallejo Highway, 7 miles from the town center. SpringHill Suites Napa Valley has 100 modern, spacious studio suites, all equipped with a panty area (microwave, refrigerator, coffee maker), large work desk, free internet access, pull-out sofa and of course the extra comfortable Marriott bedding. Free buffet breakfast is prepared each morning; for other meals there is a small selection of restaurants nearby though most are several miles north. Outdoor amenities are a pool, hot tub, patio and fire pits, while indoors the SpringHill Suites has a fitness center, 24 hour market, business center and over 6,000 sq ft of meeting/event space.