Besides Sea World, a 1.8 mile drive away at the edge of Mission Bay, Holiday Inn Express San Diego-Sea World Area is well-connected to all other area attractions via interstate 8 - the hotel is adjacent to exit 1 (Mission Bay Dr), walking distance from shopping and dining. The inn has a good reputation, for friendly, knowledgeable staff, clean rooms and nice (free) continental breakfast. Room rates are cheaper than many other nearby hotels, but facilities are still quite adequate, including an outdoor pool, whirlpool, fitness center, and a microwave/refrigerator in each room.

All 101 rooms at the Best Western Mission Bay are clean, large and equipped with a microwave & refrigerator. The inn is an older building, a typical motel design with the accommodation arranged around 3 sides of the parking lot, in front of which is an outdoor pool & hot tub. The place has a relatively quiet location along a main road but set back a little from it, beside a residential area just east of interstate 5 exit 22. The edge of Mission Bay with its adjacent parkland and footpaths is half a mile away on the other side of the interstate, with Sea World 4 miles south. Free breakfast is provided; for dinner there are a couple of restaurants adjacent.

Good staff and an easily reached location are the main plus points of the Holiday Inn Express San Diego-Mission Bay, an otherwise unremarkable 4 floor hotel in the middle of an extensive residential area, 2.4 miles from the coast. The inn is right next to interstate 5 exit 23 (Garnet St/Balboa Ave), a mile north of Mission Bay and 4 miles from Sea World; its main amenities are an outdoor pool, health/fitness center, and free continental breakfast.

Renovated in 2008, the Comfort Inn hotel near San Diego Mission Bay has 116 refrigerator/microwave-equipped rooms, and the usual amenities of a pool, hot tub, fitness center and free continental breakfast - all available at relatively low rates. The three floor building sits along Mission Bay Drive, half a mile from I-5 and right next to Mission Bay Golf Course; the waterfront is just beyond, with Sea World a 4.5 mile drive away on the south side of the bay. The Pacific Ocean at Mission Beach is 2.5 miles west.