Early 2009 saw the opening of a new Marriott hotel in Hesperia, a sister property to the adjacent SpringHill Suites: Courtyard Victorville Hesperia accommodates guests in 131 elegant rooms, all featuring free internet access, a work desk, sofa bed, refrigerator and luxurious bedding. The on-site Bistro restaurant is open for breakfast (buffet or cooked-to-order) & dinner, and there are several other restaurants a short walk away, plus several shops including Target. For those here to work, the hotel has seven meeting rooms and a full service business center. Also available are a 24 hour market, indoor pool, outdoor pool and laundry.

Hesperia's SpringHill Suites by Marriott is an affordable, all-suite hotel built in the desert a few miles west of the town center alongside interstate 15 (next to exit 143, on the opposite side from the Holiday Inn Express). The 63 guest rooms are very clean and modern, as are the public areas, which include an indoor pool, hot tub, fitness center, guest laundry and a dining area for the 'Suite Seasons' complimentary buffet breakfast. For other meals there are half a dozen restaurants just across the road.

Clean rooms, friendly staff and an easily-reached location make the Holiday Inn Express Hotel & Suites Hesperia a favorite with travelers along I-15 between Los Angeles and Las Vegas. The hotel is a new building of 100 rooms/suites on 3 floors, overlooking desert lands beside the interstate (exit 143; Main St), 3.5 miles west of the center of Hesperia and 6 miles from Victorville. Not far south rise the often snow-capped peaks of the San Gabriel Mountains. The property has an AAA 3 diamond rating, and its amenities include an indoor heated pool, fitness center, 24 hour front desk, free breakfast and staffed business center. There are several restaurants either side of the interstate including a Denny's.

Half way (3 miles) between Hesperia and Victorville, the Econo Lodge provides budget accommodation to I-15 travelers or those visiting the Mall of Victor Valley, which is just the far side of the interstate at exit 147 (Bear Valley Rd). There are many other shops and restaurants nearby though this is a generally residential neighborhood. The 50 rooms (on 2 floors) of the Econo Lodge are quite large, equipped with refrigerator/microwave, and the hotel serves free continental breakfast.