The new Holiday Inn hotel in Yuma occupies a quiet, spacious site just off exit 2 of I-8, 2 blocks from the Yuma Palms Shopping Center, and 3 miles from both the downtown area and Yuma International Airport - part of a group of other hotels built right at the edge of town, with farmland to the east and the wide, meandering Colorado River 2 miles north. The Holiday Inn is a large, full service, all non-smoking establishment with 121 rooms on 4 floors, an on-site restaurant/lounge, convenience store, fitness center, large outdoor pool, and various facilities for business & meetings. It has particularly efficient, friendly staff and is regarded by many as the top hotel in Yuma.

Even newer than the Holiday Inn (open late 2007), the Holiday Inn Express Hotel & Suites Yuma is now the easternmost hotel in town, built on farmland at the north side of I-8 exit 3 (2044 S Ave 3E), a road which leads directly to Yuma International Airport and the US Marine Air Corps Station, 2.5 miles south. Nice (free) continental breakfast is served, and for other meals there are plenty of restaurants within a mile, towards the Yuma Palms Shopping Center. The 4 floor, pet friendly hotel has 120 large extra clean rooms, an outdoor pool, hot tub, fitness center, business center, and meeting facilities catering for up to 140 guests.

A third new InterContinental Hotel Group property in Yuma opened its doors in December 2007, right next to the Holiday Inn Express at 2036 S Ave 3E. Candlewood Suites Yuma has 95 modern suites furnished with an executive work desk, LCD TV, DVD player, and a full kitchen that includes a stove, dishwasher, refrigerator/ice maker, and a microwave. Snacks and food items for cooking can be bought from the on-site convenience store, or guests can eat at one of over 20 restaurants at the Yuma Palms Regional Center, two miles west. Other facilities for extended stays include guest laundry and a (free) DVD library. For leisure, the Candlewood Suites offers a fitness center and sports court, though no pool.

In the northeast corner of Yuma, the Best Western Coronado Motor Hotel at 233 S 4th Avenue is easily reached from exit 1 (or 178) of I-8, and is just one mile south of the Colorado River and the California border, within an easy walk of the riverside Yuma State Crossing Historical Park. The hotel offers 126 rooms all on the ground floor, complimentary full breakfast, two outdoor swimming pools, hot tub, gift shop and a restaurant/lounge; this is an older building but everything is clean & well maintained, and the staff have a good reputation.

Also right next to I-8, in east Yuma, is the Best Western InnSuites Hotel & Suites, which is reached from exit 2 of the interstate - one block east on E 16th St (US 95) then a short distance north on S Castle Dome Avenue. There are 166 rooms at the hotel, including a range of suites offering different levels of amenities, together with a landscaped outdoor pool, sun deck, spa, tennis courts, exercise room, bar/cafe and meetings facilities. Good quality free hot breakfast is provided, plus a free afternoon reception. The Yuma Palms Shopping Center on the other side of the road has the best choice of restaurants and shops in town.

One of several hotels next to exit 2 of I-8 (east side), Fairfield Inn Yuma has a good reputation for comfortable rooms, friendly staff and above average free continental breakfast. The inn is 2 miles from the downtown area, 2 blocks south of the largest shopping mall in Yuma, and within 1/4 mile of several restaurants including Denny's. All 64 rooms contain a refrigerator, though no microwave; other hotel amenities are an outdoor pool, whirlpool, newsstand and guest laundry.

Long stay visitors to Yuma are well catered for by the SpringHill Suites hotel, a modern, new-looking building just east of interstate 8 exit 2, right next to the Fairfield Inn. The inn has 80 suites of various sizes, all with a mini kitchen containing refrigerator, microwave & sink; top floor rooms have far reaching views over the desert towards distant mountains. At the rear is a courtyard area with pool & hot tub, while interior facilities are an exercise room, coin-operated laundry and a dining area where free deluxe continental breakfast is served each morning.

Just up the street from the Fairfield Inn stands another clean, new Marriott property, the TownePlace Suites - a 4 floor building containing 81 two-bedroom, one-bedroom or studio suites, aimed at the extended stay market. All rooms have a full kitchen complete with dishwasher, oven, microwave and refrigerator, food for which can be purchased from the Yuma Palms Shopping Center one block north. For recreation guests have use of a fitness center and an outdoor pool/hot tub.

Along the main road through south Yuma (E 32nd St), the Quality Inn Airport hotel has an attractive setting surrounded by many tall palm trees, set back a way from the highway, and overlooking a sheltered, landscaped garden area containing the swimming pool. There are 80 rooms, all with microwave & refrigerator, plus several kitchenette suites that can accommodate up to 6 guests. Pets are welcome in some of the rooms. The inn has its own restaurant The Dunes), open for breakfast & dinner, and there are many other dining places within 2 blocks both east and west. The airport is a short distance southeast (a 3 mile drive to the terminal), while on the other side of the highway are the greens and fairways of Yuma Golf & County Club.

One of the largest (and oldest) of hotels in Yuma, the Clarion Suites offers 164 suites in a 3 floor building taking up most of one block towards the south side of the city at the junction of 4th Avenue and 26th St, 2.2 miles from I-8 exit 2. The all suite, full service hotel also has a restaurant/lounge, outdoor pool, hot tub, courtyard garden, guest laundry and newsstand. Free full breakfast is served. All the rooms have separate living/sleeping areas and are equipped with microwave & refrigerator. The Clarion Suites is recipient of the Preferred Platinum Award, the highest level of recognition for Choice Hotels.

Yuma's Comfort Inn hotel is located just southwest of exit 2 of interstate 8 in an urban neighborhood, at 1691 S. Riley Av, off E 16th St, about half way between downtown Yuma and the international airport. Like most Yuma hotels, the Comfort Inn has an outdoor pool, and also offers complimentary breakfast, 2 on-site restaurants and a newsstand. The 81 rooms are clean and recently renovated, and while not luxurious, the hotel is a good choice for mid range accommodation. There are 2 adjacent fast food restaurants.

Recently taken over by the Rodeway Inn chain, this budget motel features a nice pool lined by shady trees, plus an outdoor hot tub; interior amenities are guest laundry and free continental breakfast. The inn is located along 4th Avenue (business 8 loop) - a busy street lined with shops, restaurants and all other necessary facilities. There are 120 rooms in the hotel - small but comfortable - all containing a refrigerator, and some with a microwave.

79 room Comfort Inn & Suites Yuma enjoys sweeping views over the desert and the nearby Gila Mountains - the hotel is built next to exit 12 of interstate 8 near the village of Fortuna, ten miles east of Yuma. The road past the hotel links with US 95 which heads due north, reaching Kofa NWR after 40 miles. The inn is a quiet, reasonably-priced and well managed establishment, offering an outdoor pool, fitness center, and free continental breakfast. There are several restaurants within walking distance, though most other facilities are at least 6 miles away, close to Yuma.